Faculty of Medical Sciences > Clinical Hematology > Research & Publication
Research activities:
Areas of Research:
Cytokine polymorphism in ITP
Bone marrow changes and newer advances in ITP
Gene polymorphism in aplastic anemia
Advances in CML
Myelodysplastic syndrome
Hematological abnormalities in HIV
Hemophilia
Ph. D Program
"Role of cytokines in gene polymorphisms and its expression level in etiopathogenesis of acquired aplastic anemia" (Ongoing)
"Micronutients (Vitamin B12, Vitamin D3 and Zinc) status and its implication in Patients with hematological malignancies (Ongoing)
Regulation of polyamine biosynthesis and the role of interferon in patients with CML (awarded)
S Phase fraction and aneuploidy in patients with bone marrow aplasia (Awarded)
Study of oxidative stress in CML (Awarded)
Study of immune reconstitution inflammatory syndrome associated tuberculosis in HIV infected patients on Anti-retroviral therapy (Awarded)
Polymorphism study in proinflammatory cytokines gene in patients with ITP (ongoing).
Research Lab
Basic investigations
PCR, electrophoresis, cell culture, cytogenetics.
Publications (Last 5 years):
Prof A.K. Tripathi
Singh N, Tripathi AK,Sahu DK, Mishra A, Linan M, Argente B et al. Diffrential genomics and transcriptomics between tyrosine kinase inhibitor-sensitive and -resistant BCR-ABL dependent chronic myeloid leukemia. Oncotarget 2018 (advance publication)
Jain M, Kumar A, Verma SP, Tripathi AK. The ubiquitous parasite: leishmaniasis in an elderly man. Blood Research 2018; 53: 101
Yadav DK, Tripathi AK, Gupta D, Shukla S, Singh AK, Kumar A, Agarwal J, Prasad K. Interleukin 1B (IL-1B-31 and IL-1B-511) and interleukin 1 receptor antagonist (IL1-Ra) genes polymorphisms in Primary Immune Thrombocytopenia. Blood Research 2017; 52: (in press)
Jain M, Tripathi AK. CD8 expression in B Chronic Lymphocytic Leukemia: A case of Immunophenotypic aberrancy. Cytometry Part B: Clinical Cytometry. 2017; DOI:10.1002/cyto.b.21535
Jain M, Shukla A, Kumar A, Kushwaha R, Tripathi AK. Anemia in CD5 negative chronic lymphoproliferative disorders: Importance of bone marrow examination. J Clinical and Diagnostic Research. 2017; 11(4):XL01
Tripathi AK, Verma SP, Kumar N. Mutation analysis in Chronic Myeloid Leukemia patienst in chronic phase on Imatinib having delayed achievement of milestones or loss of response. Indian Journal of Hematology and Blood Transfusion.2017: 33(3); 316-320
Shukla M, Agarwal M, Singh JV, Tripathi AK, Srivastawa AK, Singh VK. Nonadherance to antiretroviral therapy among people living with HIV/AIDS attending two tertiary care hospitals in districts of northern India. Ind J Community Medicine. 2016; 41:55-61
Arunachalam AK, Jain M, Kumar A, Kushwaha R, Singh US, Tripathi AK. Megakaryocytes in chronic phase of chronic myeloid leukemia: A descriptive case series. Annals of Pathology and Laboratory Medicine. 2016; 3:A176-182
Singh AK, Awasthi D, Dubey M, Nagarkoti S, Kumar A, Chandra T, Barthwal MK, Tripathi AK, Dixit M. High oxidative stress adversely affects NFB mediated induction of inducible nitric oxide synthase in human neutrophils: Implications in chronic myeloid leukemia. Nitric Oxide. 2016;58 :28-41
Yadav M, Singh AK, Kumar H, Rao G, Chakravarti B, Gurjar A, Dogra S, Kushwaha S, Vishwakarma AL, Yadav PN, Datta D, Tripathi AK, Chattopadhyay N, Trivedi A, Sanyal S. Epidermal growth factor receptor inhibitor cancer drug gefitinib modulates cell growth and differentiation of acute myeloid leukemia cells via histamine receptors. Biochemica et Biophysica Acta (BBA) - General Subjects 2016; 1860, issue 10:2178-2190.
Parashar Y, Kushwaha R, Kumar A, Agarwal K,Singh U.S, Jain M,Verma S P, Tripathi A K. Haemostatic profile in patients of Myeloproliferative Neoplasms- A Tertiary Care Centre Experience. Journal of Clinical and Diagnostic Research. 2016 nov, 10(11):ECO1-ECO4 (DOI:10.7860/JCDR/19985.8840)
Shukla M, Agarwal M, Singh JV, Tripathi AK, Srivastava AK, Singh VK. High-risk sexual behavior among people living with HIV/AIDS attending tertiary care hospitals in district of Northern India.Ind J Sexually Transmitted Diseases and AIDS 2016;37: 46-51
Yadav D, Tripathi AK. Association of TNF-α -308G>A and TNF-β +252A>G genes polymorphisms with Primary Immune Thrombocytopenia: A north Indian study. Blood Coagulation & Fibrinolysis 2015, 26:00-00 doi:10.1097/mbc.00000000000492
Singh N, Sahu DK, Purwar P, Gupta S, Tripathi AK, Dixit J, Kant R, Gupta DK. CGH array based case report of a patient suffering with amelogenesis imperfect, Jalili syndrome, situs invertus and oligozoospermia. J Genetic Disorders & Genetic Reports 2015;4:1. Doi: 10.4172/2327-5790.1000122
Shukla M, Agarwal M, Singh JV,Tripathi AK, Srivastava AK, Singh VK. Catastrophic Health Expenditure amongst People Living with HIV/AIDS Availing Antiretroviral Treatment Services at Two Tertiary Care Health Facilities in District of Northern India. National J of Community Medicine. 2015;6(3):323-328
Singh N, Bansal B, Singh U, Qureshi S, Tripathi AK. Comparative study of preinvasive and invasive lesions of the cervix in HIV positive and HIV negative women. Clinical Cancer Investigation Journal. 2015; 4:39-42
Singh R, Singh RK, Massod T, Tripathi AK, Mehdi AA, Singh RK, Schwartzkopff O, Cornelissen O. Circadian time structure of circulating plasma lipid peroxide, antioxidant enzymes and other small molecules in peptic ulcers. Clinica Chimica Acta. 2015; 451: 222-226
Rai D, Garg RK, Mehdi AA, Jain A, Verma R, Tripathi AK et al. Cerebrospinal fluid cytokines and matrix metalloproteinases in human immunodeficiency seropositive patients of tuberculous meningitis. Annals of Indian Academy of Neurology. 2014;17:171-178.(10.4103/0972-2327.132617)
Saxena R, Gupta S, Singh K, Mitra K, Tripathi AK, Tripathi RK. Proteomic profiling of Sup T1 cells reveal modulation of host proteins by HIV1 Nef variants. PLOS one DOI:10,1371/journal.pone.0122994, April 13, 2014
Jangamreddy JR, Panigrahi S, Lotfi K, Yadav M, Maddika S, Tripathi AK, Sanyal S, Los MJ. Mapping of Apoptin interaction with BCR-ABL 1, and development of apoptin based targeted therapy. Oncotarget 2014; 5:7196-7211
Tripathi AK, Shukla A, Misra S, Yadav YK, Yadav DK. Eltrombopag therapy in newly diagnosed steroid non responsive ITP patients. International J of Hematology 2014 DOI 10.1007/s12185-
Dr S.P.Verma
Jain M, Kumar A, Verma S P, Tripathi A K. The Ubiquitous parasite: leishmaniasis in an elderly man. Blood Research.2018;53 (2):101.
Dutta T.K, Diljith H,Vishnu V Y, Verma S P, Charles D, Vinod K V, Basu D. Long term outcome of splenectomy in chronic immune mediated thrombocytopenic purpura. International Journal of Hemtology Research.2017;3(1):164-167.
Dutta T K, Verma S P, Nayak R, Basu D,Vinod KV, Kar R. Hemophagocytic Lymphohistiocytosis in adults and adolescents ; Experience from a tertiary care centre in south India. National Journal of Laboratory Medicine 2017;6(1):io01-io05.
Tripathi AK, Verma SP, Kumar N. Mutation analysis in Chronic Myeloid Leukemia patient in chronic phase on Imatinib having delayed achievement of milestones or loss of response. Indian Journal of Hematology and Blood Transfusion.2016 (accepted, in press) DOI: 10.1007/s12288-016-0755-y
R Kushwaha, S.Chauhan, A Kumar, U S Singh, A I Jain, S.P.Verma, M Kumar, S.Babu. Hematological and Immunophenotypic profile of acute myeloid leukemia: An experience from a developing country. Virchow Archiv 2016; 469:s290-s290
Verma SP, Subbiah A, Kolar Vishwanath V, et al. Bleomycin-induced skin toxicity: is it always flagellate erythema?. BMJ Case Rep 2016. doi:10.1136/bcr-2014-204575
Parashar Y, Kushwaha R, Kumar A, Agarwal K,Singh U.S, Jain M,Verma S P, Tripathi A K. Haemostatic profile in patients of Myeloproliferative Neoplasms- A Tertiary Care Centre Experience. Journal of Clinical and Diagnostic Research. 2016 nov, 10(11):ECO1-ECO4 (DOI:10.7860/JCDR/19985.8840)
Verma SP, Dutta TK, Mahadevan S, Nalini P, Basu D, Biswal N et al. A randomized study of very low dose factor VIII prophylaxis in severe haemophilia- A success story from a resource limited country. Haemophilia 2016;1-7 DOI:10.1111/hae.12838
Verma SP, Subbiah A, Jacob SE, et al. Chronic myeloid leukemia with extreme thrombocytosis. BMJ Case Rep 2015 .Published online: doi:10.1136/bcr-2014-204564
Jain N, Reddy M Dandu, Verma S.P. Khanna R, Vaish AK, Usman K, Tripathi AK Singh A, Mehrotra S; Gupta A. cardiac abnormalities in HIV-positive patients ; results from an observational study in India. I Int Assoc provid AIDS care 2014;13(1):40-6.
Review articles:
Agarwal MB, Varma S, Mahapatra M, Tripathi AK, Bhave A et al. Balancing efficacy and bleeding risk in the prevention of stroke due to atrial fibrillation with newer oral anticoagulants: a consensus statement from the Indian Society of Hematology and Transfusion Medicine. Ind J Hemat Blood trans 2012: 28; 129-143
Chandra S, Tripathi AK, Misra S, Mohammad A, Vaish AK. Physiological changes in hematological parameters in pregnancy. Ind J Hemat Blood trans 2012: 28; 144-146
Kumar Rashmi, Tripathi AK, Khanna M. Neurological Manifestations of HIV infection in children. Reviews in Neurology (Indian Academy of Neurology) 2008 P 265-286
Tripathi AK. Guidelines on the management of occupational exposure to HIV and recommendations for post exposure prophylaxis. Current Medical Journal 2008: 14; 21-26
Presentation at conferences: (Last 5 years):
International: Presented a paper at International CML conference at Estoril, Portugal. 26-29 Sept. 2013.
American Society of Hematology Conference at Atlanta USA, 8-12 Dec 2012 and presented a paper.
International symposium on CML. Mumbai 28-29 July 2012
World Congress of Hemophilia. Paris 8-12 July 2012
International Conference on Hemato-oncology, University of Hong Kong & MD Anderson Cancer Center USA. 23-26 Feb 2012.
American Society of Hematology Conference at San Diego USA, 6-9 Dec 2011
International Conference on Hemato-oncology, National University of Singapore & MD Anderson Cancer Center USA. At Singapore 18-20 March 2011.
International AIDS Society conference, Vienna Austria, 18-23 July 2010
International AIDS Society conference, Cape town, S Africa, 19-22 July 2009
American Society of Hematology Conference at New Orleance USA, 6-9 Dec 2009
International Symposium on Prognostic and Predictive Factors in Cancer Management Dec 15, 2008. CSM Medical University Lucknow
American Society of Hematology Conference at San Francisco USA, 6-9 Dec 2008
IXth International Congress on Drug Therapy in HIV Infection. Glasgow 9-13 Nov. 2008
National:
Chaired a session during Advances in Flowcytometry at SGPGI Lucknow. 20 Sept, 2013
Participated as member of National Consultative Group on Thalassemia, Delhi. 10 & 11 August, 2013
Chaired a session on PPTCT at National Conference of ISPRB, Lucknow March 24, 2013
Lecture on "HIV and TB" at Workshop on TB at RML Institute of medical Sciences, Lucknow March 18, 2013
Attended in workshop on Biostatistics at Annual conference of INCLEN, Lucknow March 2, 2013
Lecture on Iron Overload/Chaired a session at National Hematology Conference, Bombay Hospital, Mumbai, Jan 23-26, 2013
Lecture at "HIV conference" at Mumbai, 5 Jan 2013
Hemophilia update. CMC Vellore November 20, 2012
Lecture on IRIS at 5th AIDS Society of India conference, Bangalore, November 23, 2012
Participated in Update on inherited hemoglobin disorders. Deptt of Pathology, KG Medical University Lucknow November 17, 2012.
Moderator in "MDS Symposium" at Annual conference of Indian Society of Hematology and Blood Transfusion, Puri November 9, 2012.
Guest lecture "MDS: Recent advances" Dept. of Medicine, KG Medical University Lucknow. October 10, 2012
Guest lecture "How I diagnose and manage a case of MDS" at National CME at Medical College Calicut. 16 September 2012
Chaired a session "Implication of NAT in blood banking" at KG Medical University Lucknow 4 Sept 2012
Chaired a session on "Medical research; Need and how to do" at symposium at CSSMU Lucknow 14 April 2012
An Update on thrombocytopenia CSMMU Lucknow 6 April 2012; Lecture on " ITP, intriguing issues"
National Hematology Update AIIMS New Delhi 7-8 April 2012; panel discussion on CML: second line TKA
National conference on Hemostasis, Bangalore 18 March 2012; Lecture on "Status of hemophilia care in UP"
HIV Conference at Mumbai 16-17 March 2012. Lecture on "Predictors of IRIS in HIV"
Panel discussion on new oral anticoagulant. Mumbai 10 March 2012
National Hematology Conference Mumbai 26-29 Jan 2012; Lectrure on Hematological disorder in HIV
Annual Conference of Association of Physicians of India Odisha, 13 Nov, 2011 and delivered lecture on "Acute Leukemia: Approach"
Annual Conference of Indian Society of Hematology and Blood Transfusions at PGI Chandigarh, 10-12 November,, 2011 and chaired sessions.
National update on Hemophilia Management. HFI Delhi 18 July 2011
Panel discussion on the "2nd line TKI in CML" at Best of ASCO meeting at Pune 17 July 2011
"Myeloma and renal involvement" chaired session, Lucknow 3 June 2011
Lecture "Initiation of ART" at AIDS Conference at MLN Medical College Allahabad 1 May 2011
Panel Judge in Poser competition at Association of Physiologists and Pharmacologists of India UP meeting, CSM medical University Lucknow 22 April 2011
"Advances in Management of Hemostatic disorders" participated at Chennai organized by CMC Vellore April 10, 2011
Panel discussion on "Anti microbial resistance" during World Health Day programme ornaized by CSM medical university & WHO Lucknow April 7, 2011
Lecture on "HIV: ART initiation" at National Master trainers's training programme, STM Kolkata. March 23, 2011
National Hematology Update 2011, at AIIMS 26-27 Feb 2011. Lecture on "TTP"
Chaired session on CML at ASH update, Jan 16, 2011 Delhi
Lecture "HAART and Bone Marrow" at National AIDS Conference, Mumbai Jan 7-8, 2011
Lecture "Microangiopathic hemolytic anemia" at National Hematology CME, Bombay Hospital Jan 27-30 , 2011
Lecture " Lymphoma and HIV" and chaired a session in National HIV Conference Mumbai, Jan 8-10. 2010
Lecture "DIC; recent advances" and chaired sessions during Hematology Update, Bombay Hospital. Jan. 14-16, 2010
Chaired a session during "National Myeloma Update" at Mumbai organized by Indian Society of Hematology and Bombay Hospital. May 17, 2009
Chaired a session and member of Panel discussion during "Symposium on Hematology for physicians" at Govt. Medical college Chandigarh May 3, 2009
Chaired and delivered lecture on "Hemophilia and Myths" on World Hemophilia Day 17 April, 2009 at SIPS Lucknow
Chaired a session during "CME on Clinical Aspects of Transfusion Medicine" !7 Jan 2009 CSM Medical University Lucknow
Lecture on "Erythropoietin" at National Hematology CME at Bombay Hospital Mumbai 24-26 Jan 2009.
Lecture on "Thrombocytopenia in HIV Disease" at National Conference on HIV Therapy, Mumbai 10-11 Jan 2009
Delivered a lecture on "HIV and hematological disorder" at ISHTM 2008 Pondicherry Sept.
Lecture during "Symposium on MDS" at Bombay Hospital, Mumbai, 26-27 July 2008
Attended and delivered lecture in HIV conference 2008 at Mumbai
Academic activities:
Intradepartmental:
Seminars on various hematology topics every Monday.
Interdepartmental:
Hematology group discussions every alternate Tuesday along with the staff from heamtopathology unit, department of pathology and paediatrics hematology.
Inter institutional:
Lucknow hematology group meeting every 2-3 months
Miscellaneous:
A State level Hematology quiz under auspices of Indian Society of Hematology & Blood Transfusion May 17, 2013
International update on CML at KG Medical University, March 25, 2013.